Recruiting
NA
INTERVENTIONAL
NCT03321201
Cauterization Versus fibrin Glue for Conjunctival Autografting in Primary Pterygium Surgery
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
Pterygium is a noncancerous growth of the conjunctival tissue over the cornea. It is a progressive disease that may lead to visual impairment in advanced stages, as well as restriction of ocular motility, chronic inflammation and cosmetic concerns. Surgical removal is the treatment of choice, but recurrence of pterygium is a frequent problem. In this randomized controlled cauterization will be compared with fibrin glue for conjunctival autografting in primary pterygium surgery.
Interventions
Name:
Cauterization
Type:
PROCEDURE
Description:
To ensure the stability of the graft during cuttings, four sealing wraps will be installed, which will be removed after cauterisation is completed. Autograft and conjunctiva will be approximated by surgical forceps and will be cauterized using a bipolar cutter (Erbe ICC 50) with a force 1-3 / 20. Forceps will be released slowly to prevent elevation of the graft. The same procedure will be performed 10 times until graft is well firmed. Graft stability will be checked up with a sponge and additional cauterization will be preformed if needed.
Name:
Fibrin glue
Type:
PROCEDURE
Description:
Fiber adhesive (Tissel 1 mL kit4-iu) will be prepared according to manufacturer's instructions. Preparation time will be approximately 10-15 min per kit. Once mixed the fibrin glue is usable up to 4 h. For the purpose of the study preparation of the fibrin glue will be performed by a nurse.
Primary Outcomes
Measure:
Recurrence of pterygium
TimeFrame:
180 days
Description:
Any re-growth of tissue from the area of excision across the limbus onto the cornea.
Trial Information
NCT ID
NCT03321201
Status
Recruiting
Study Type
INTERVENTIONAL
Phases
NA
Sponsor
University of Split, School of Medicine
Last Updated
December 15, 2025