A mouse study looked at how a sleep‑related peptide called delta‑sleep inducing peptide (DSIP) changes immune signals in the heart, especially when the animals are exposed to loud noise. DSIP didn’t change two key immune proteins (IL‑1 and IL‑2) but did raise IL‑6, a molecule linked to inflammation. Loud noise itself also raised IL‑1 and IL‑6 in the heart. The peptide didn’t affect IL‑6 levels in the brain.

Quantitative shifts in the content of interleukine-1, -2 and -6 of the myocardium of mice under the conditions of acoustic stress and delta-sleep inducing peptide action are studied. It has been shown that injection of delta-sleep inducing peptide has no effect on the level of interleukine-1 and -2 in the myocardial tissue, whereas the quantity of interleukine-6 increased. The level of interleukine-1- and -6 in the myocardium were increased and no significant changes were observed in the level of interleukine-2 under the noise action. Interleukine-1- and -2 were not detected in the hypophysis of experimental animals of all groups (intact, under acoustic stress, under delta-sleep inducing peptide application). The level of interleukine-6 in the hypothalamus decreased under conditions of acoustic stress, whereas administration of delta-sleep inducing peptide has no effect on its level. The obtained data are considered in the context of immune modulating properties of delta-sleep inducing peptide.