[Effect of delta-sleep inducing peptide on free-radical processes in the brain and liver of mice during various light regimens].
Voĭtenkov. V B VB; Popovich. I G IG; Arutiunian. A V AV; Oparina. T I TI; Prokopenko. V M VM
Key Findings
- Constant illumination raised brain oxidative markers by ~20% and cut liver glutathione‑peroxidase activity by ~60% in mice.
- Under normal light, Deltaran increased brain antioxidant activity by 9% and liver superoxide‑dismutase by 17%, while lowering liver glutathione‑peroxidase by 82%.
- Under constant light, Deltaran reduced liver oxidative chemiluminescence by 23%, boosted overall liver antioxidant activity by 19%, and also lowered liver glutathione‑peroxidase by 69%.
Practical Outcomes
- The peptide appears to have antioxidant effects in mice, especially when the light‑dark cycle is disturbed. However, the study is limited to animals, uses a very small dose, and provides no human safety or efficacy data, so it isn’t ready for direct use by biohackers. More research is needed before considering it in real‑world protocols.
Summary
In a mouse study, a peptide called Deltaran was given under normal day/night cycles and under constant light. Constant light made the brain more oxidative and lowered a key liver antioxidant enzyme. Deltaran improved several antioxidant measures in both normal and constant‑light conditions, suggesting it may act as an antioxidant, especially when light cycles are disrupted.
Abstract
Female SHR mice received 5-days long course of delta-sleep inducing peptide preparation "Deltaran" subcutaneously in daily dose of 5 mkg/mice per 24h under standard light regime (12h light: 12 h darkness) or constant illumination. Free-radical level and antioxidative activity in brain and liver was studied by standard methods. Constant illumination increased chemiluminescence in brain by 20 % and decreased liver glutationperoxidase activity by 60 %, as compared to the mice kept in standard light regime. In conditions of standard light regime deltaran increased levels of general antioxidative activity in brain by 9%, liver superoxide dismutase by 17% and lowered levels of glutationperoxidase of liver by 82%. In conditions of constant illumination Deltaran lowered levels of chemiluminescence in liver by 23%, raised the general antioxidative activity in liver by 19% and lowered levels of glutationperoxidase of liver by 69%. It was supposed that deltaran has an antioxidant effect under constant light regime.
Study Information
pubmed
2008