[Searching for the optimal combinations of regulator anxiolytic peptides: theoretical rationale].
Koroleva. S V SV; Ashmarin. I P IP
Key Findings
- A vector‑based method was created to rank regulatory peptide complexes for anxiolytic (anti‑anxiety) effects.
- The method generated a shortlist of nine peptide combos, many involving NPY paired with DSIP or other peptides.
- The authors suggest these combos be studied experimentally next, but no dosing or safety data are provided.
Practical Outcomes
- For biohackers, the study offers a theoretical menu of peptide mixes to explore, but it lacks any real‑world testing, dosage guidance, or safety information. It may help shape future self‑experiments, but you’d need to wait for experimental validation before trying these combinations.
Summary
The paper describes a computer‑based way to pick pairs or groups of brain‑active peptides that might reduce anxiety with fewer side effects. It lists several combos that include the peptide DSIP, but it doesn’t test them in people or animals.
Abstract
A vector method is proposed to initially select the complexes of regulatory peptides (RPs) with certain functional characteristics. As the result of a theoretical search for the optimal combinations of anxiolytic RPs with different spectra of side effects, the following complexes are proposed for subsequent experimental investigation: NPY-ANP, NPY-SP, NPY-NT, NPY-CGRP, NPY-DSIP, NPY-MIF-1, NPY-SP-MIF-1, NPY-ANP-DSIP, and NPY-CGRP-DSIP.
Study Information
pubmed
2001