[Regulatory effect of delta sleep-inducing peptide on the activity of antioxidant enzymes in erythrocytes and tissues of rats during cold stress].
Bondarenko. T I TI; Miliutina. N P NP; Shustanova. T A TA; Mikhaleva. I I II
Key Findings
- A single intraperitoneal dose of DSIP (12 µg per 100 g body weight) increased superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activities.
- Glutathione concentrations in red blood cells, liver, and brain were also elevated after DSIP administration.
- The antioxidant boost occurred in both healthy rats and rats subjected to cold‑stress, suggesting a stress‑resilient effect.
Practical Outcomes
- While the study shows DSIP can enhance antioxidant defenses in rats, the findings are based on an injection route and animal model, so they cannot be directly applied to human self‑experimentation. Biohackers should view this as preliminary evidence of a possible antioxidant benefit, but more human research is needed before any dosing or protocol can be recommended.
Summary
In rats, giving the peptide delta sleep‑inducing peptide (DSIP) by injection boosted the activity of several antioxidant enzymes and raised glutathione levels in blood, liver and brain, both under normal conditions and when the animals were exposed to cold stress.
Abstract
Antioxidant system's state of erythrocytes and tissues in rats under normal and cold stress conditions was studied. Intraperitoneal injection of exogenic DSIP at the dose of 12 mkg/100 g body weight both, to intact and to cold-exposed animals results in the increase of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase activities and concentration of glutathione in red blood cells, liver and brain.
Study Information
pubmed
1999