1996
pubmed
[A rotational syndrome induced by administration of the delta sleep-inducing peptide into the reticular portion of the rat substantia nigra].
Shandra. A A AA; Godlevskiĭ. L S LS; Vast'ianov. R S RS; Zaporozhchenko. M B MB; Ibragim. M M; Brusentsov. A I AI; Oleĭnik. A A AA
Key Findings
- Unilateral intranigral DSIP injection induces contralateral rotational behavior in rats.
- Naloxone prevents the rotational effect, suggesting opioid system involvement.
Practical Outcomes
- For self‑directed health optimizers, this research offers no actionable guidance. It does not provide dosage, safety, or efficacy data for humans, nor does it suggest any protocol that could be applied outside a laboratory setting.
Summary
Injecting the peptide DSIP into a specific brain area of rats caused them to spin in circles, and this effect could be blocked by naloxone or made stronger by haloperidol. The study is purely experimental and done in rats, with no clear link to human health or practical use.
Abstract
Unilateral intranigral administration of a delta-sleep-induced peptide (DSIP) evoked a contralateral rotation. Naloxon prevented development of the effect whereas haloperidol administration enhanced the DSIP cataleptogenic effect.
Study Information
Provider
pubmed
Year
1996