[Changes in the rate of protein biosynthesis in the organs of mice under the action of the delta sleep-inducing peptide and psychoemotional stress].
Rikhireva. G T GT; Sokolova. I S IS; Rylova. A V AV; Kopylovskiĭ. S A SA; Mikhaleva. I I II; Prudchenko. I A IA
Key Findings
- A single intraperitoneal injection of DSIP (120 mg/kg) increased protein synthesis rates in mouse brain, liver, and spleen.
- When mice were exposed to psycho‑emotional stress, DSIP altered the timing and magnitude of stress‑induced changes in protein synthesis.
- The authors suggest DSIP’s adaptogenic action may be due to its modulatory effect on the regulatory system of protein biosynthesis.
Practical Outcomes
- While the results hint that DSIP can influence protein production and stress responses, the study used very high doses in mice and an injection route that isn’t practical for humans. There’s no clear guidance on safe or effective dosing for people, so biohackers can’t directly apply this to a protocol yet.
Summary
A study in mice found that giving a high dose of the delta‑sleep‑inducing peptide (DSIP) by injection boosted protein production in the brain, liver, and spleen and changed how stress affected that protein production. The researchers think DSIP’s stress‑protective (adaptogenic) effects may come from this influence on protein synthesis.
Abstract
The effects of delta-sleep-inducing peptide (DSIP) and its analogs (ID-6 and ID-12) on the protein synthesis rate in the mouse brain, liver, and spleen were studied with special reference to mechanisms underlying the adaptogenic action of DSIP. Time-related changes of the protein synthesis rate were estimated in the mouse organs after a single intraperitoneal injection of the peptide (120 mg/kg body weight) and the psycho-emotional stress with or without preliminary (1 h before) injection of the peptide. After DSIP administration, the protein biosynthesis was activated and the dynamics of stress-induced changes of biosynthesis were modified. The data obtained suggest that the mechanisms underlying the DSIP adaptogenic action involve its modulatory effect on the regulatory system of protein biosynthesis.
Study Information
pubmed
1995