[Synthesis and biological properties of new analogs of delta-sleep peptide. I. Antiepileptic effect].
Prudchenko. I A IA; Stashevskaia. L V LV; Mikhaleva. I I II; Ivanov. V T VT; Shandra. A A AA; Godlevskiĭ. L S LS; Mazarati. A M AM
Key Findings
- 11 DSIP analogues were synthesized with changes at positions 1, 2, and 6.
- Several analogues showed stronger antiepileptic effects than native DSIP in animal seizure models.
- Effective doses were 50 µg/kg centrally in rats and 1 mg/kg peripherally in mice.
Practical Outcomes
- The study hints that modified DSIP could be a more potent anti‑seizure agent, but it’s still early‑stage animal work. No human dosing or safety data exist, so biohackers should not try these compounds yet. Keep an eye on future research for possible neuroprotective or cognitive benefits, but wait for clinical validation.
Summary
Scientists created 11 new versions of the delta‑sleep peptide (DSIP) by tweaking three spots in its structure. When tested in rats and mice, a few of these analogues stopped seizures better than the original peptide, both when injected directly into the brain and when given peripherally.
Abstract
To study structure-functional relationship in the series of DSIP, eleven DSIP analogues varying in positions 1, 2 and 6 were synthesized by the solid-phase method using both Boc- and Fmoc-approaches. The antiepileptic action of these analogues was compared with that of DSIP. The seizure activity was induced by the corazol or picrotoxin i. p. injection. Some analogues proved more efficient as antiepileptic agents than DSIP after their central (50 micrograms/kg in rats) and peripheral (1.0 mg/kg in mice) administration.
Study Information
pubmed
1993