[The predisposition to catatonic reactions, monoamine oxidase and the delta-sleep peptide in rats].
Voĭtenko. N N NN; Kolpakov. V G VG
Key Findings
- Catatonia‑prone rats show a higher MAO‑B/MAO‑A ratio, caused by lower MAO‑A and higher MAO‑B activity.
- DSIP administration normalizes the MAO‑B/MAO‑A ratio in both laboratory and wild catatonic rats.
- DSIP completely abolishes the susceptibility to catatonic reactions in these rats.
Practical Outcomes
- DSIP appears to modulate monoamine‑oxidase activity and prevent catatonia‑like states in rats, hinting at possible neuro‑protective or mood‑stabilizing effects. However, the study is limited to animals, so there is no direct protocol or dosage guidance for humans. Biohackers should view this as early mechanistic evidence that warrants further human research before any practical application.
Summary
In rats that are naturally prone to catatonic (freeze‑like) reactions, the balance between two brain enzymes (MAO‑B and MAO‑A) is shifted toward more MAO‑B activity. Giving the peptide DSIP (delta‑sleep‑inducing peptide) restores the normal enzyme balance and stops the cats‑like reactions, suggesting DSIP can affect brain chemistry linked to catatonia.
Abstract
MAO B/MAO A rations and the influence of delta-sleep inducing peptide (DSIP) on the two forms of MAO and on the predisposition to different types of catatonic reactions were compared in rats of GC strain selected from Wistar for predisposition to catalepsy, and in wild rats. In GC rats, the MAO B/MAO A ratio was increased, as compared to Wistar, in the brain stem and hemispheres, whereas in wild rats predisposed to catatonia it was increased, as compared to normal wild rats, only in the hemispheres. In GC rats, this increase of the MAO B/MAO A ratio was due to a decrease of MAO A and increase of MAO B activity, while in wild catatonic rats only due to heightened MAO B activity. Administration of DSIP abolished the susceptibility to catatonic reactions and normalized the MAO B/MAO A ratio both in GC and in wild catatonic rats. There seems to be a partial similarity of physiological mechanisms of catatonic reactions in laboratory albino and in wild rats.
Study Information
pubmed
1991