[The delta sleep-inducing peptide as a factor enhancing the content of substance P in the hypothalamus and the resistance of rats to emotional stress].
Salieva. R M RM; Ianovskiĭ. K K; Ratsak. R R; Trofimova. Ia I IaI; Oehme. P P; Sudakov. K V KV; Iumatov. E A EA
Key Findings
- DSIP (60‑120 nmol/kg, i.p.) increased substance P content in the hypothalamus of male rats.
- Both single and daily DSIP doses boosted substance P in rats that were prone to stress.
- A single 60 nmol/kg DSIP injection reduced classic stress markers such as adrenal hypertrophy and thymus involution.
Practical Outcomes
- The study hints that DSIP could be a tool for improving stress resilience by modulating substance P, but the work is limited to rats and uses intraperitoneal injection. For biohackers, it suggests a potential benefit of DSIP for stress management, yet human dosing, safety, and delivery routes remain untested, so any protocol would be highly experimental.
Summary
In rats, giving the peptide delta‑sleep‑inducing peptide (DSIP) raised levels of the brain chemical substance P and helped the animals cope better with emotional stress. A single dose also cut down typical stress signs like enlarged adrenal glands and shrinking thymus.
Abstract
The influence of the delta-sleep inducing peptide (DSIP, 60 and 120 nmol/kg, intraperitoneally) on the content of substance P (SP) in rats hypothalamus was studied on males of August line. DSIP administration significantly increased the mean SP content in the hypothalamus and also its content in animals, stable and predisposed to emotional stress. Daily DSIP administration before putting the rats in conditions of stress increased the SP content in the hypothalamus decreased at the emotional stress. Preliminary single DSIP administration to the animals subjected to stress also increased the SP content. Single DSIP administration in a dose of 60 nmol/kg sharply reduced classical stress manifestations, such as hypertrophy of adrenals and thymus involution.
Study Information
pubmed
1991