[The effect of the delta-sleep peptide on the adrenaline level in rat tissues under normal conditions and during cold stress].
Bondarenko. T I TI; Krichevskaia. A A AA; Sheĭkina. I V IV; Kiriukhina. E V EV
Key Findings
- A single 12 µg/100 g dose of DSIP raised brain adrenaline at 1, 3, 6, and 24 hours after injection.
- Liver adrenaline rose at the same early time points and stayed higher for up to 3 days.
- Adrenal gland adrenaline increased at 1 hour and 1 day, then dropped 41% after 2 days; under cold stress DSIP amplified adrenaline gains in all three tissues.
- Overall, DSIP triggers a short‑term surge in catecholamines, especially when the animal is already stressed.
Practical Outcomes
- For biohackers, this suggests DSIP is not just a sleep aid—it also stimulates the body's stress hormone system, which could affect metabolism, alertness, and cardiovascular load. If you plan to use DSIP, be aware it may cause a temporary adrenaline spike, especially in stressful or cold environments, and the long‑term impact on health is unknown.
Summary
In rats, a single dose of the sleep‑related peptide DSIP caused a temporary rise in adrenaline (the fight‑or‑flight hormone) in the brain, liver, and adrenal glands. The increase lasted a few hours to a few days, and under cold‑stress conditions DSIP made the adrenaline boost even larger. After a couple of days the adrenal gland adrenaline level actually fell.
Abstract
Adrenalin content in the brain, liver and adrenal glands under the effect of cold stress grows by 314, 500 and 56% as compared to the control. A single administration of the delta-sleep inducing peptide (DSIP) in a dose of 12 microgram/100 g to intact animals makes the adrenalin content in the brain higher 1, 3, 6 and 24h after administration; two and three days later the adrenalin content in the brain does not change. The amount of adrenalin in the liver of the same animals increases 1, 3, 6 h and 1, 2, 3 days after DSIP administration. Intraperitoneal administration of DSIP induces an increase of the adrenalin level in the adrenal glands of rats an hour and a day after administration. Two days later the level of adrenaline decreases by 41%; 3, 6 h and 3 days after DSIP administration the content of adrenaline remains unchanged. As a result of the DSIP administration in a dose of 12 micrograms/100 g to the animals in the state of cold stress, the content of adrenalin increases in the rat brain by 129, in the liver--by 300, adrenal glands--by 44% as compared with the control.
Study Information
pubmed
1990