[Distribution of labeled amino acids and delta-sleep inducing peptide in the body after instillation into the conjunctiva of the rabbit eye].
Badikov. V I VI; Gitel'. E P EP; Ivanova. N Ia NIa; Ivolgina. L G LG; Fedianina. M G MG; Zaĭtsev. D A DA; Miasoedov. N F NF; Sudakov. K V KV
Key Findings
- DSIP applied to the eye reaches the bloodstream and distributes to the brain within 10 minutes.
- Peak concentration in the visual cortex occurs around 2 hours after ocular administration.
- Significant early accumulation is also seen in cardiac tissue, spleen, and the optic chiasm.
Practical Outcomes
- The study suggests that eye drops could be a fast way to get DSIP into the brain, but it was done in rabbits and used radioactive tracers, so it isn’t directly usable for humans. Biohackers should view this as a proof‑of‑concept for alternative delivery routes, not a ready‑to‑use protocol.
Summary
In a rabbit study, scientists put a tiny amount of the sleep‑inducing peptide DSIP (and some amino acids) onto the eye surface. Within 10 minutes the peptide showed up in many body parts, including the brain, and reached its highest level in the visual part of the brain after about 2 hours. It also appeared quickly in the heart, spleen and the optic chiasm.
Abstract
Dynamics of 3H-valine, 3H-glycine and 3H-DSIP distribution in various brain structures, tissues and liquids of an organism due to administration of these substances in eye conjunctive were studied in rabbits with scintillation spectrometry method. Marked amino acids and DSIP were observed in all substrates in 10 min after administration. Maximal activity was found in 2 h in the brain visual cortex and in 30 min in cardiac tissue, spleen and optical chiasma.
Study Information
pubmed
1990