[Delta sleep-inducing peptide as a modulator of mediators acting on the heart].
Ul'ianinskiĭ. L S LS; Zviaginstseva. M A MA; Kosharskaia. I L IL
Key Findings
- DSIP (6 µM) enhanced the negative chronotropic (heart‑slowing) effect of acetylcholine in rabbit hearts
- DSIP reduced the positive chronotropic (heart‑speeding) effect of noradrenaline
- The study was performed on isolated rabbit hearts, not in living organisms
Practical Outcomes
- At this stage there’s no actionable protocol for biohackers—no human dosing or safety data. The findings are interesting for future research on heart‑rate control, but they don’t translate into a usable supplement or therapy yet.
Summary
A lab study on isolated rabbit hearts found that delta sleep‑inducing peptide (DSIP) can change how the heart responds to chemicals that normally speed up or slow down the heartbeat. It made the slowing effect of acetylcholine stronger and reduced the speeding effect of noradrenaline, hinting it might influence heart rate regulation, but the work was done in animal tissue at high concentrations and isn’t ready for human use.
Abstract
Experiments on 51 isolated rabbit hearts have documented, that delta sleep-inducing peptide (6 X 10(-6) M/l) has a modulating effect on the mediators influencing the heart. This peptide enhances negative chronotropic effect of acetylcholine (1 X 10(-6) M/l) and decreases positive chronotropic effect of noradrenaline (1 X 10(-6) M/l). Such effect may be one of mechanisms of changes in the extracardiac regulation on the heart influenced by this peptide.
Study Information
pubmed
1990