[Comparison of the effects of DSIP and SP 1-11 on stress-induced chronic sleep disorders in rats].
Wachtel. E E; Koplik. E E; Kolometsewa. I A IA; Balzer. H U HU; Hecht. K K; Oehme. P P; Ivanow. V T VT
Key Findings
- SP1‑11 was more effective than DSIP at correcting stress‑induced hyposomnia in rats.
- Both peptides altered sleep duration, the proportion of sleep stages versus wakefulness, and the timing of sleep cycles.
- The study highlighted both shared and distinct mechanisms of action between SP1‑11 and DSIP.
Practical Outcomes
- For DIY biohackers, this suggests that DSIP may not be the most potent option for stress‑related sleep problems, at least based on animal data. Substance P (SP1‑11) could be worth exploring, but human studies are lacking, so any use would be experimental and unverified. Proceed with caution and prioritize safety and further research before trying either peptide for sleep enhancement.
Summary
In stressed rats that couldn’t sleep well, a peptide called substance P (SP1‑11) helped them get back to normal sleep better than another peptide called DSIP. The two peptides changed how long the rats slept, how much time they spent in different sleep stages, and the pattern of their sleep cycles, but SP1‑11 showed stronger overall effects.
Abstract
In the present paper the effects of substance P (SP1-11, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) and delta sleep inducing peptide (DSIP, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) to normalize the deprivation of sleep in chronically stressed rats with hyposomnia were investigated. The results indicated that SP1-11 is more potent than DSIP in rats with stress-induced hyposomnia. Different effects were found in the duration of sleep, the percentage of sleep phases compared to wake phases, the rhythm of sleep phases and the time periods of sleep-cycles. Based on the present results both the common and differences in the mode of action were discussed.
Study Information
pubmed
1987