[Analysis of the mechanism of the stress-protective action of delta sleep-inducing peptide].
Iukhananov. R Iu RIu; Rozhanets. V V VV; Mikhaleva. I I II; Maĭskiĭ. A I AI
Key Findings
- Six‑hour immobilization raised corticosterone, ACTH, and beta‑endorphin in rat blood.
- Stress also increased met‑enkephalin in adrenal glands while lowering it in the brain’s striatum.
- A single intraperitoneal dose of DSIP (0.1 mg/kg) partially blocked the corticosterone increase, with no effect on the other measured hormones.
Practical Outcomes
- DSIP may modestly blunt the cortisol response to acute stress in rats, suggesting a potential anti‑stress benefit. However, the effect was small, limited to one hormone, and the study used an animal model with an injection route not typical for humans. For biohackers, the data provide a hint that DSIP could help manage stress spikes, but more human research is needed before recommending a specific dosage or protocol.
Summary
In rats that were stressed by being tied up for six hours, the stress hormone cortisol (corticosterone) and other stress chemicals went up. Giving the peptide DSIP at a low dose reduced the cortisol rise a bit, but didn’t change the other stress markers. The authors think DSIP’s stress‑protective effect works through the brain‑pituitary‑adrenal system.
Abstract
By RIA there were studied the contents of corticosterone, ACTH, beta-endorphin and insulin in the blood plasma, met- and leu-enkephalin in different regions of the rat brain and in the adrenal glands after a 6-hour immobilization. The stress increased the content of corticosterone, ACTH, beta-endorphin, but not insulin in the blood plasma, and the levels of met-enkephalin in the adrenal glands, but decreased the met-enkephalin contents in the striatum. The injection of DSIP (0.1 mg/kg, i/p) blocked partly the elevation of corticosterone only. The authors propose, that stress-protective action of DSIP is realized with the involvements of the hypothalamo-pituitary-adrenal gland system.
Study Information
pubmed
1990