[Effect of delta sleep-inducing peptide, anticonvulsant preparations and nicotinamide on generalized seizure activity].
Shandra. A A AA; Godlevskiĭ. L S LS; Mazarati. A M AM; Makul'kin. R F RF
Key Findings
- DSIP increased the time before the first seizure appeared for seizures induced by corazol, bicuculline, and picrotoxin.
- DSIP reduced the severity of seizures caused by corazol and bicuculline, especially when seizures were mild.
- When given together with phenobarbital, carbamazepine, diphenylhydantoin, or nicotinamide, DSIP enhanced the anticonvulsant effects of these drugs.
- The most effective dose range in mice was 10‑100 µg/kg.
Practical Outcomes
- For biohackers, DSIP shows a modest potential as a seizure‑modulating agent and as a possible booster for existing anti‑seizure medications, but all data are from mice and no human studies exist. Until safety and dosing are clarified in people, it’s not ready for everyday use or performance protocols.
Summary
In mouse experiments, a tiny peptide called delta‑sleep‑inducing peptide (DSIP) made seizures start later and be less severe when the seizures were triggered by certain chemicals. The effect was strongest at doses between 10 and 100 micrograms per kilogram, and DSIP also boosted the seizure‑blocking power of several common anti‑seizure drugs.
Abstract
The influence of delta-sleep inducing peptide (DSIP) upon seizures induced by corazol, bicuculline, picrotoxin, strychnine, thiosemicarbazide were investigated in experiments on F1(CBA X C57 BL/6) mice. It was shown that DSIP increased the latency of first seizure manifestation which were induced by corazol, bicuculline and picrotoxin and also resulted in a suppression of seizure severity of corazol and bicuculline induced seizures. Anticonvulsant action of DSIP was evident under the condition of the mild severity seizures development. The effect of DSIP was mostly pronounced in range of its doses from 10 to 100 mcg/kg. DSIP when combined with phenobarbital, carbamazepine, diphenylhydantoin or nicotinamide enhanced the antiepileptic effects of these anticonvulsant drugs.
Study Information
pubmed
1989