[The effect of delta sleep-inducing peptide on the convulsive activity in corasol kindling].
Shandra. A A AA; Godlevskiĭ. L S LS; Kryzhanovskiĭ. G N GN; Makul'kin. R F RF; Mikhaleva. I I II
Key Findings
- DSIP (100 µg/kg i.p.) delayed the onset of generalized seizures in a kindling model.
- DSIP reduced overall seizure activity and lowered mortality in the animals.
- The antiepileptic effect persisted from 5 minutes to 24 hours after dosing.
Practical Outcomes
- DSIP shows promise as an anticonvulsant and neuroprotective agent in animal studies, but there is no human data or safe dosing guidance. For biohackers, it is not yet a usable protocol for seizure prevention or brain health, and more research is needed before considering self‑administration.
Summary
In a study on rats and mice, giving a small dose of the peptide delta‑sleep‑inducing peptide (DSIP) slowed down the development of seizures, reduced how severe the seizures were, and lowered the death rate of the animals. The protective effect lasted from a few minutes up to a full day after the injection and was not blocked by the opioid blocker naloxone.
Abstract
The influence of intraperitoneal delta-sleep inducing peptide (DSIP) injection (100 micrograms/kg) on the epileptic activity was investigated in the experiments on Wistar rats and (CBA X C57B1/6)F1 mice. The model of chronically developing epileptic activity--the model of pharmacological kindling--was created by daily repeated corasole injections in subconvulsive doses (30 mg/kg). It has been shown that DSIP injection delayed the manifestation of generalized seizures during kindling, led to the suppression of seizure activity and reduced the mortality rate of animals that developed kindled seizures. The antiepileptic effect of DSIP was observed throughout the period of 5 minutes to 24 hours after the injection. Naloxone (2.5 mg/kg) did not change the antiepileptic effect of DSIP.
Study Information
pubmed
1988