[Antimetastatic effect of the delta-sleep peptide during stress in mice with Lewis' lung carcinoma].
Shmal'ko. Iu P IuP; Mikhaleva. I I II
Key Findings
- DSIP reduced stress‑induced metastatic spread in mice with Lewis lung carcinoma.
- Neurohumoral (stress‑related hormone) levels were more stable with DSIP treatment.
- Lipid peroxidation and cathepsin activity in blood vessels and lung tissue decreased when DSIP was administered.
Practical Outcomes
- For biohackers, DSIP shows some promise as a stress‑modulating and antioxidant‑supporting peptide, but the evidence is limited to a cancer mouse model. There is no human data on safety or efficacy for healthy people, so it cannot be recommended as a routine longevity or performance supplement at this time. More research is needed before practical protocols can be designed.
Summary
In a mouse study, giving the peptide delta‑sleep (DSIP) during the stressful period after removing a lung tumor reduced the spread of cancer cells. The peptide also helped keep stress‑related hormones stable and lowered signs of oxidative damage and certain enzymes that can break down tissue.
Abstract
The experiments on C57Bl mice with metastatic Lewis lung carcinoma have shown that peptide delta-sleep (DSIP) lowers the stimulation of metastatic spreading which is observed in combination of the surgical removal of the tumour with the emotional-painful stress. The antimetastatic effect is accompanied by stabilization of neurohumoral indices, by a decrease in the intensity of lipid peroxidation and of the acid cathepsin activity in the blood vessels and in the lung tissue.
Study Information
pubmed
1988