[Effect of the delta sleep peptide on epileptic activity in the cerebral cortex of rats and cats].
Kryzhanovskiĭ. G N GN; Shandra. A A AA; Godlevskiĭ. L S LS; Karpova. M N MN; Mikhaleva. I I II
Key Findings
- Intraperitoneal DSIP (100 µg/kg) suppressed penicillin‑induced epileptic spikes in rats.
- DSIP also reduced severe ictal discharges in the same rat model.
- Intravenous DSIP (100 µg/kg) lowered strychnine‑induced seizure activity in cats.
Practical Outcomes
- The study shows DSIP can dampen seizure activity in animal models, hinting at possible anti‑seizure or neuroprotective effects. However, the work is pre‑clinical, uses high doses, and does not provide guidance for human use, so it isn’t ready for self‑experimentation or protocol development by biohackers.
Summary
In animal experiments, giving the peptide delta sleep‑inducing peptide (DSIP) at a dose of 100 µg per kilogram reduced seizure‑like brain activity caused by chemicals in both rats and cats. The peptide seemed to calm down both moderate and severe epileptic spikes.
Abstract
In free behaviour experiments on rats it has been shown that the intraperitoneal injection of delta sleep-inducing peptide (DSIP) (100 micrograms/kg) suppressed penicillin-induced relatively moderate epileptic foci which generated spike potentials as well as severe foci with ictal epileptic discharges. In the experiments on cats it was shown that intravenous DSIP injection (100 micrograms/kg) suppressed strychnine-induced epileptic focus and complexes of epileptic foci.
Study Information
pubmed
1987