Study of delta sleep-inducing peptide efficacy in improving sleep on short-term administration to chronic insomniacs.
Monti. J M JM; Debellis. J J; Alterwain. P P; Pellejero. T T; Monti. D D
Key Findings
- DSIP slightly reduced the number of night awakenings and the time it took to fall into non‑REM sleep, but these reductions were not statistically significant versus placebo.
- Total sleep time and non‑REM sleep increased mainly because stage 2 sleep went up; deep sleep (stages 3‑4) and REM sleep stayed the same.
- Overall, the sleep improvements observed with DSIP were judged to be of little clinical significance.
Practical Outcomes
- DSIP does not appear to be an effective or reliable sleep aid for chronic insomniacs. The modest changes observed are unlikely to provide meaningful benefits, so biohackers should prioritize other proven sleep‑optimization strategies over DSIP supplementation.
Summary
Giving the peptide DSIP intravenously to people with chronic insomnia showed tiny changes in sleep patterns, but these changes weren’t statistically meaningful compared to a placebo and didn’t translate into noticeable real‑world benefits.
Abstract
The effects of delta sleep-inducing peptide (DSIP), on the sleep cycle of insomniac patients were assessed by means of polysomnographic recordings. DSIP in a dose of 25 nmol/kg or a placebo was administered i.v. during four nights using a double-blind crossover design. The number of nocturnal awakenings, non-rapid-eye-movement (NREM) sleep latency, total waking time and waking time after sleep onset were decreased under DSIP treatment, but no significant differences were found in comparison to baseline or to double-blind placebo nights. Total sleep time and NREM sleep time were increased by the peptide. Their increase was related to increases in stage 2, while stage 1, slow wave sleep (stages 3 and 4) and rapid-eye-movement sleep were not modified. For NREM sleep time and stage 2 sleep differences between DSIP and a placebo were significant, but the same differences existed already for the baseline values. It can be concluded that sleep improvement under DSIP treatment is of little clinical significance.
Study Information
pubmed
1987