[The effect of naloxone and delta-sleep inducing peptide on the homocarnosine content of brain tissue].
Makletsova. M G MG; Mendzheritskiĭ. A M AM; Uskova. N I NI; Choraian. I O IO; Baĭich. M M
Key Findings
- Naloxone administered to the brain or bloodstream reduces homocarnosine in specific rabbit brain regions.
- Intravenous DSIP does not alter homocarnosine levels in rabbit brain tissue.
- Intraperitoneal (belly‑cavity) DSIP sharply increases homocarnosine content in rat brain.
Practical Outcomes
- The results suggest DSIP can affect brain chemistry, but only when given by a specific route in rodents, and the impact on humans or performance is unknown. For biohackers, there’s no clear dosing guideline or proven benefit, so it’s not ready for practical use. More human‑focused research is needed before incorporating DSIP for longevity or cognitive gains.
Summary
A study in rabbits and rats looked at how the drug naloxone and a peptide called delta‑sleep‑inducing peptide (DSIP) change levels of a brain molecule called homocarnosine. Naloxone lowered homocarnosine in several brain areas, while giving DSIP directly into the bloodstream did nothing. Giving DSIP into the belly cavity of rats, however, caused a big rise in homocarnosine.
Abstract
The intraventricular and intravenous administration of naloxone was studied for its effect on the homocarnosine amount in cerebral hemispheres, striatum, hippocamp, hypothalamus, thalamus, cerebellum, medulla oblongata as well as in the spinal cord of rabbits. The intracysternal administration of naloxone decreases the homocarnosine amount in the striatum, hypothalamus, cerebellum and medulla oblongata. The intravenous administration of peptide exerts no statistically reliable effect on the homocarnosine content in the rabbit brain. The intraperitoneal administration of delta-sleep-inducing peptide increases sharply the homocarnosine content in the rat brain.
Study Information
pubmed
1989