[Effect of delta sleep-inducing peptide (DSIP) on slow sleep in the rabbit].
Griniavichius. K A KA; Milashius. A M AM
Key Findings
- Intravenous DSIP at 30 nmol/kg was tested in rabbits using blind experiments.
- No statistically significant change in the duration of slow (deep) sleep was observed compared with control.
- A non‑significant trend showed a decrease in deep sleep and increased motor activity about two hours after dosing.
Practical Outcomes
- For biohackers looking for a peptide to boost deep sleep, DSIP appears ineffective and may even reduce it slightly. There’s no actionable dosing protocol for sleep enhancement, so it’s not recommended as a sleep aid based on this data.
Summary
A study gave rabbits a dose of delta sleep‑inducing peptide (DSIP) and measured deep (slow) sleep. The peptide didn’t significantly change how long the rabbits slept, and there was even a slight trend toward shorter deep sleep and more movement a couple of hours after the injection. So DSIP doesn’t act as a strong sleep‑promoting drug in this animal model.
Abstract
The influence of the delta sleep-inducing peptide on the rabbit slow sleep was studied in "blind" experiments following the intravenous injection of its 30 nmol/kg dose. The duration of the slow sleep was assessed by the summary duration of ECoG sections of the sensorimotor and visual cortex with pronounced delta-activity. The results obtained after the injection of peptide and that of a control substance (saccharose) were compared with those obtained before the injection. No statistically significant differences were found. A tendency was observed towards a decrease in the duration of the slow sleep and increased motor activity of the animal at the second hour after peptide injection. Hence, the delta sleep-inducing peptide is not a substance with pronounced hypnogenic properties.
Study Information
pubmed
1982