[Role of benzodiazepine receptors in realizing the anxiolytic effect of compounds on intact rats and on animals with a physical dependence ethanol].
Burov. Iu V IuV; Orekhov. S N SN; Iukhananov. R Iu RIu; Vedernikova. N N NN
Key Findings
- DSIP and several other compounds reduce anxiety without acting on benzodiazepine receptors.
- In alcohol‑dependent rats, the reduction in anxiolytic activity of these compounds does not correlate with increased binding affinity for diazepam.
- Diazepam’s anxiolytic effect is linked to benzodiazepine receptors, unlike DSIP.
Practical Outcomes
- For DIY biohackers, DSIP might offer anxiety relief without the typical benzodiazepine‑related tolerance or dependence issues, but the evidence is limited to animal studies. No specific dosing or protocol is provided, so any self‑experimentation should start with very low doses and be approached cautiously.
Summary
The study shows that Delta Sleep Inducing Peptide (DSIP) can calm rats, but it does this through a different brain pathway than classic anti‑anxiety drugs like diazepam. In rats that are dependent on alcohol, the drop in DSIP's calming effect doesn't line up with changes in the usual benzodiazepine receptor binding, suggesting a separate mechanism.
Abstract
Anxiolytic activity of DSIP, sodium hydroxybutyrate, nicotinoyl-GABA, mebicar, some derivatives of aminoandrostane and beta-carboline was not, like in the case of diazepam and beta C-3CEE, related to benzodiazepine receptors. The degree of the decrease in anxiolytic activity of these compounds did not correspond to increasing Ki binding of 3H diazepam in alcoholic rats.
Study Information
pubmed
1986