[Olygopeptide KND as a putative endogenous prototype of delta sleep inducing peptide (DSIP). Comparative study of biological properties].
Mikhaleva. I I II; Ivanov. V T VT; Voĭtenkov. V B VB; Vechkanov. E M EM; Bondarenko. T I TI
Key Findings
- KND (WKGGNASGE) is a naturally occurring peptide found within the JMJD1B histone demethylase protein.
- In vivo experiments showed KND has comparable sleep‑related activity to DSIP, with stronger antioxidant and anticonvulsive effects.
- The authors propose KND could be the endogenous prototype of DSIP, meaning the body may naturally produce it.
Practical Outcomes
- For now, the data are pre‑clinical, so there’s no dosage or safety information for humans. The study hints that KND might eventually be a more potent alternative to DSIP for sleep, stress, or neuro‑protective purposes, but biohackers should wait for further research before trying it.
Summary
Researchers compared the well‑known sleep peptide DSIP with a newly identified, very similar peptide called KND. In animal tests KND showed the same effects as DSIP and even stronger antioxidant, anti‑seizure and behavior‑modifying actions, suggesting it might be the natural version of DSIP in the body.
Abstract
We have undertaken a comparative study on physiological activity of well known neuropeptide DSIP (WAGGDASG E) and new closely related peptide KND (WKGGNASGE) in vivo assays. The sequence of K2, N5-DSIP (KND) was found recently by the computer search for DSIP homologous sequences in available nucleotide and protein databases at 324-332 site of Lysine-specific demethylase 3 B (EC 1.14.11, Swiss-Prot: Q7LBC6.1, 1-1761aa). This human lysine-specific histone demethylase is a representative of the recently discovered family of so called JmjC-domain-containing histone demethylases encoded by JMJD1B gene and ubiquitously expressed in tissues of various mammalian species. Biological investigations performed in this work confirm our preliminary data that DSIP-related peptide KND exhibits the similar biological properties in comparison with DSIP. Assessed by us antioxidative, anticonvulsive and behavioral effects of KND were even more expressed than in DSIP case. These results provide the additional evidences to support our suggestion that KND can be a possible endogenous prototype of "real" DSIP.
Study Information
pubmed
2013
10.1134/s1068162013030096