Correction of cerebral ischemia in low-resistant animals with an antistress drug Deltaran.
Gannushkina. I V IV; Konorova. I L IL; Koplik. E V EV; Antelava. A L AL
Key Findings
- Deltaran reduced EEG slow‑wave amplitude and restored neuronal reactivity after carotid artery blockage in rats.
- Treated rats showed 100% survival and no neurological symptoms despite induced cerebral ischemia.
- The drug did not alter overall cerebral blood flow but increased blood supply to active neuronal units.
Practical Outcomes
- The results suggest that an antistress drug could offer neuroprotection during acute brain ischemia, but the evidence is limited to animal models. No human dosing, safety, or efficacy data exist, so it isn’t ready for self‑experimentation or protocol development by biohackers.
Summary
In a rat study, the drug Deltaran (an antistress compound) helped protect the brain after a simulated stroke. It lowered slow brain waves, kept neurons responsive, and all treated rats survived without neurological problems, even though overall blood flow in the brain didn't change.
Abstract
Deltaran decreased the amplitude of EEG slow waves and restored neuronal reactivity after carotid artery occlusion in Wistar rats sensitive to cerebral ischemia. Deltaran had no effect on local cerebral blood flow. This drug increased blood supply to a unit of neuronal activity in the brain of intact animals during the acute stage of cerebral ischemia, provided 100% survival rate of rats with cerebral ischemia, and prevented the development of neurological symptoms in survivors. Animal experiments proved the possibility of correcting cerebral ischemia with antistress drug Deltaran.
Study Information
pubmed
2006
2006-03-01T00:00:00.000Z
10.1007/s10517-006-0152-x
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