Effects of delta sleep-inducing peptide on pre- and postsynaptic glutamate and postsynaptic GABA receptors in neurons of the cortex, hippocampus, and cerebellum in rats.
Grigor'ev. V V VV; Ivanova. T A TA; Kustova. E A EA; Petrova. L N LN; Serkova. T P TP; Bachurin. S O SO
Key Findings
- DSIP dose‑dependently potentiates GABA‑activated currents in hippocampal and cerebellar neurons.
- DSIP blocks NMDA‑induced potentiation in cortical and hippocampal neurons.
- DSIP alters presynaptic NMDA receptor activity, reflected by changes in calcium uptake into cortical synaptosomes.
Practical Outcomes
- The findings hint that DSIP might boost inhibitory GABA signaling while dampening excitatory NMDA signaling, which could be of interest for sleep or neuro‑protective strategies. However, the research is limited to rats and provides no human dosage or safety data, so biohackers should treat it as mechanistic insight rather than a ready‑to‑use protocol.
Summary
In rats, the peptide called delta sleep‑inducing peptide (DSIP) makes the brain's inhibitory GABA signals stronger and blocks the excitatory NMDA signals. This effect depends on the dose and was seen in several brain areas, suggesting DSIP could influence sleep and brain activity, but the study is purely animal‑based.
Abstract
We studied the effect of delta sleep-inducing peptide on GABA receptors of hippocampal and cerebellar neurons in rats. It was shown that delta sleep-inducing peptide considerably and dose-dependently potentiates GABA-activated currents in these neurons and blocks NMDA-activated potentiation in cortical and hippocampal neurons. The peptide modulates activity of presynaptic NMDA receptors, which is seen from changes in (45)Ca(2+) uptake into synaptosomes of the brain cortex after uptake stimulation with glutamate and NMDA.
Study Information
pubmed
2006
2006-08-01T00:00:00.000Z
10.1007/s10517-006-0323-9
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