Deltaran prevents an adverse effect of emotional stress on the course of cerebral ischemia in low-resistant animals.
Konorova. I L IL; Gannushkina. I V IV; Koplik. E V EV; Antelava. A L AL
Key Findings
- Emotional stress made blood flow drop more in the left side of the brain during a stroke in low‑resistance rats.
- Deltaran boosted blood flow in the left hemisphere and kept overall brain blood supply stable during the acute phase of ischemia.
- Treatment with Deltaran lowered mortality by roughly 62% and eased stroke symptoms, with the biggest effect in the left hemisphere.
Practical Outcomes
- While the results are promising, they come from an animal model and don’t provide dosage or safety info for humans. For now, it’s a research signal rather than a usable protocol, but it suggests Deltaran could be explored for neuro‑protective strategies in stress‑related stroke risk.
Summary
In a rat study, the peptide Deltaran helped keep blood flowing in the brain after a stroke, especially in animals that were stressed beforehand. It cut death rates by about two‑thirds and improved blood supply to brain cells, mainly on the left side of the brain.
Abstract
Local cerebral blood flow in the left hemisphere decreased most significantly in low-resistant Wistar rats preexposed to emotional stress. Deltaran selectively increased blood flow in the left hemisphere and improved blood supply to neuronal activity unit of the brain in these animals. This drug prevented progressive decrease in local cerebral blood flow in both hemispheres during the acute stage of ischemia. The effect of Deltaran was related to modulation of collateral blood flow and adequate blood supply to neuronal activity unit in the brain tissue. Deltaran decreased the mortality rate (by 62%) and alleviated the symptoms of cerebral ischemia. The positive effect of Deltaran was more pronounced in the left hemisphere.
Study Information
pubmed
2006
2006-05-01T00:00:00.000Z
10.1007/s10517-006-0221-1
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