Human plasma DSIP decreases at the initiation of sleep at different circadian times.
Seifritz. E E; Müller. M J MJ; Schönenberger. G A GA; Trachsel. L L; Hemmeter. U U; Hatzinger. M M; Ernst. A A; Moore. P P; Holsboer-Trachsler. E E
Key Findings
- Plasma DSIP levels drop significantly at the moment of sleep onset in both evening and morning sleep.
- The DSIP decrease occurs alongside changes in EEG slow‑wave activity, cortisol, and growth hormone.
- No specific sleep stage (REM, NREM, etc.) showed a unique relationship with DSIP levels.
Practical Outcomes
- For biohackers, the study suggests that DSIP naturally falls when you fall asleep, so adding extra DSIP to boost sleep onset may not be necessary. It also highlights that measuring DSIP levels should consider the timing relative to sleep, as levels change rapidly at sleep start. No direct dosing or protocol changes are recommended based on this data.
Summary
In a small study of seven healthy men, the amount of delta‑sleep‑inducing peptide (DSIP) in the blood fell sharply right when they fell asleep, whether they went to bed at night or after being kept awake. This drop happened together with normal sleep‑related brain waves and hormone changes, but it wasn't tied to any particular sleep stage.
Abstract
Nocturnal plasma delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) was determined serially in seven healthy male subjects. Time courses during nocturnal sleep (2300-0800 h), nocturnal sleep deprivation (2300-0500 h), and morning recovery sleep (0500-0800 h) after sleep deprivation were compared. A significant decrease in plasma DSIP-LI was found at the transition from wakefulness to sleep in both evening sleep (2300 h) and morning recovery sleep (0500 h). Time courses were accompanied by physiological changes in sleep electroencephalographic slow-wave activity, and in plasma concentrations of cortisol and human growth hormone. No sleep stage specificity was found. It is concluded that DSIP is influenced by the initiation of sleep.
Study Information
pubmed
1995
1995-12-31T00:00:00.000Z
10.1016/0196-9781(95)02027-6
7
38