1995
pubmed
Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress.
Khvatova. E M EM; Rubanova. N A NA; Prudchenko. I A IA; Mikhaleva. I I II
Abstract
Metabolic effects of delta-sleep inducing peptide (DSIP) under hypoxia stress were investigated in rats subjected to short-term hypoxic conditions (about 0.26 Bar). It was found that DSIP partially restricted stress-induced changes in activity of mitochondrial monoamine oxidase type A (MAO-A) and serotonin level in rat brain. A number of DSIP analogues was tested and among them there were some compounds with enhanced ability to counteract hypoxia induced changes in MAO-A activity and serotonin content in comparison with native neuropeptide.
Study Information
Provider
pubmed
Year
1995
Date
1995-07-17T00:00:00.000Z
DOI
10.1016/0014-5793(95)00661-r