Expression of the c-fos gene during emotional stress in rats: the clocking effect of delta sleep-inducing peptide.
Sudakov. K V KV; Umryukhin. P E PE; Koplik. E V EV; Anokhin. K V KV
Key Findings
- Emotional stress sharply raises c‑fos gene activity in specific brain regions of stress‑prone rats.
- An intraperitoneal dose of DSIP (60 nmol/kg) blunted this stress‑induced c‑fos increase.
- The suppressive effect was strongest in the paraventricular hypothalamus and septum of rats predisposed to stress.
Practical Outcomes
- DSIP could potentially be used to dampen acute stress responses, but the study is limited to rats and uses a high injection dose not directly comparable to human use. Biohackers should view this as early mechanistic evidence rather than a ready‑to‑apply protocol, and await human trials before adjusting dosages or expectations.
Summary
In rats that are naturally more prone to stress, a single injection of the peptide delta sleep‑inducing peptide (DSIP) reduced the brain's immediate stress‑response signal (c‑fos gene activity). This suggests DSIP may have an anti‑stress effect, at least in animal models.
Abstract
Emotional stress induced more marked increases in the expression of the c-fos gene in limbo-reticular structures of the brain in rats prognostically predisposed to emotional stress. I.p. doses of delta sleep-inducing peptide (DSIP) (60 nmol/kg) weakened the stress-induced expression of the c-fos gene. This effect was more apparent in animals predisposed to emotional stress, in which preliminary injections decreased stress-induced c-fos expression in the paraventricular hypothalamus and the medial and lateral parts of the septum. The decreased expression of the early gene c-fos in emotional stress after preliminary dosage with DSIP may reflect the leading mechanism of the anti-stress action of this peptide.
Study Information
pubmed
2001
10.1023/a:1012381413726