Protective effect of Biolan during ischemic damages to cultured cerebellar granular cells.
Khaspekov. L G LG; Klyushnik. T P TP; Dupin. A M AM; Lyzhin. A A AA; Bezrukov. M V MV
Key Findings
- Biolan protected cultured cerebellar granular cells from ischemic injury (oxygen and glucose deprivation).
- Biolan reduced cell death caused by glutamate toxicity.
- The study suggests Biolan could have potential for treating ischemic brain damage.
Practical Outcomes
- The findings are promising but come from an in‑vitro rat model, so there is no human dosage or protocol yet. For biohackers, it hints that combining carnosine with DSIP might offer neuroprotective benefits, but more research is needed before it can be applied in real‑world health routines.
Summary
A product called Biolan, which mixes the amino‑acid carnosine with the delta sleep‑inducing peptide (DSIP), was shown to protect young rat brain cells in a dish from damage caused by lack of oxygen/glucose and from excess glutamate.
Abstract
Biolan containing carnosine and delta sleep-inducing peptide produced a protective effect on cerebellar granular cells from 7-day-old rats exposed in culture to ischemia (oxygen and glucose deprivation) and cytotoxic influence of glutamate. These results indicate that Biolan holds much promise for correction of ischemic brain damages in clinical practice.
Study Information
pubmed
2002
10.1023/a:1015534419149