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DSIP

Emideltide, DSIP nonapeptide, Delta sleep-inducing peptide

Quick Stats
Studies 458
Trials 82
Overview Studies Clinical Trials
Score 2
1993 pubmed

Circadian effects of beta-endorphin, melatonin, DSIP, and amphetamine on pentylenetetrazol-induced seizures.

Yehuda. S S; Mostofsky. D I DI

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Key Findings

  • DSIP (like beta‑endorphin) increased seizure thresholds during the night but not during the day.
  • All tested drugs, including DSIP, made rats more seizure‑prone during daytime compared to saline.
  • The authors suggest dopaminergic pathways might explain the circadian differences in drug effects.

Practical Outcomes

  • If you’re using DSIP for any neuro‑protective or performance purpose, the study hints that timing could matter—night‑time dosing might be more beneficial than daytime. However, the data come from rats and focus on seizure susceptibility, so direct recommendations for humans are speculative. Treat this as a modest insight that encourages further research rather than a ready‑to‑use protocol.

Summary

In a rat study, giving DSIP (the same peptide some biohackers use) changed how easily the animals had seizures, and the effect depended on the time of day. At night DSIP raised the seizure threshold (making seizures less likely), while during the day it didn’t help and even made the animals slightly more vulnerable compared to a saline control. The researchers think dopamine may be involved in this time‑dependent effect.

Abstract

Circadian effects on PTZ-induced seizure thresholds alone and following drug pretreatment were studied in 720 male rats, divided into 40 groups of 18 each. Each rat was tested only once, at one of eight clock hours and under one of five drug pretreatments. Clear cyclic changes in thresholds were found. Drug effects on the rhythm were similar for DSIP and beta-endorphin, which produced higher thresholds during the night periods, while d-amphetamine and melatonin decreased the threshold during that period. All drugs increased the vulnerability to seizures relative to the saline control during the daytime, while only beta-endorphin and DSIP offered improved protection during the night hours. The possibility of dopaminergic mediation is suggested to account for the effects.

Study Information

Provider

pubmed

Year

1993

DOI

10.1016/0196-9781(93)90030-k