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DSIP

Emideltide, DSIP nonapeptide, Delta sleep-inducing peptide

Quick Stats
Studies 458
Trials 82
Overview Studies Clinical Trials
Score 2
1992 pubmed 18 citations

Implication of tryptophan in the stimulatory effect of delta-sleep-inducing peptide on indole secretion from perifused rat pineal glands.

Ouichou. A A; Pévet. P P

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Key Findings

  • Both DSIP and tryptophan increase melatonin and 5‑methoxy‑tryptophol secretion in a dose‑dependent manner
  • Blocking amino‑peptidase stops DSIP’s effect, indicating the peptide must be degraded to release tryptophan
  • Inhibiting tryptophan hydroxylase reduces DSIP‑induced melatonin release, confirming tryptophan’s role

Practical Outcomes

  • DSIP could theoretically be used to boost melatonin by providing tryptophan, but the data are from isolated rat glands and use very high concentrations. No clear human dosing or safety info is available, so biohackers should treat this as a mechanistic clue rather than a ready‑to‑use protocol.

Summary

In rat pineal gland experiments, the peptide DSIP was found to raise melatonin levels, but it does this by breaking down into the amino acid tryptophan, which then drives melatonin production. The effect disappears when the breakdown process is blocked, showing DSIP works like a tryptophan source rather than directly stimulating melatonin.

Abstract

We have recently demonstrated that delta-sleep-inducing peptide (DSIP) stimulates indolamine secretion from rat pineal glands. In the present study, we show that tryptophan (TRP), as well as DSIP, stimulate melatonin (MEL) and 5-methoxy-tryptophol (5-ML) secretion in a dose-dependent manner between 5 x 10(-6) and 10(-4) M. The kinetic characteristics of the MEL and 5-ML secretion and the response induced by the two substances were similar. The increase in MEL secretion in response to 10(-4) M DSIP was completely inhibited by pretreatment of the pineals with 10(-5) M phenanthroline (amino-peptidase inhibitor), suggesting that stimulatory effect of DSIP was due to TRP liberated by peptide degradation. This mechanism occurring in the pineal was confirmed using 10(-4) M para-chlorophenylalamine (TRP hydroxylase inhibitor), which reduced the pineal response to 10(-4) and 10(-5) M DSIP by 50 and 100%, respectively.

Study Information

Provider

pubmed

Year

1992

Date

1992-03-01T00:00:00.000Z

DOI

10.1159/000109313

Citations

18