Delta sleep-inducing peptide administration does not influence growth hormone and prolactin secretion in normal women.
Giusti. M M; Carraro. A A; Porcella. E E; Valenti. S S; Nicora. D D; Sessarego. P P; Giordano. G G
Key Findings
- DSIP (25 µg/kg IV) did not raise or lower basal GH or prolactin levels in healthy women.
- When combined with arginine (a known GH secretagogue), DSIP did not alter the hormone response.
- A nighttime DSIP infusion did not change the normal circadian pattern of GH or prolactin.
Practical Outcomes
- For biohackers looking to use DSIP to boost growth hormone or prolactin, this study suggests it’s ineffective at the tested dose and route. It provides a safety checkpoint that DSIP won’t unexpectedly spike these hormones, but it also indicates no performance or longevity benefit via GH modulation.
Summary
In a small study of eight healthy women, giving delta sleep‑inducing peptide (DSIP) at a dose that changes heart‑rate patterns did not change the levels of growth hormone or prolactin, either on its own or when combined with an arginine boost. The peptide also didn’t shift the normal daily rhythm of these hormones.
Abstract
The aim of this study was to analyze the effects of delta sleep-inducing peptide (DSIP) on growth hormone (GH) and prolactin (PRL) secretion in eight healthy women with normal cycles (aged 17-36 years). GH and PRL secretion was studied in five women after DSIP (25 micrograms/kg bw IV over 30 min), arginine chlorhydrate (0.5 g/kg bw IV over 30 min) and simultaneous DSIP plus arginine chlorhydrate administration. In three other women the circadian rhythm of GH and PRL was studied during DSIP (25 micrograms/kg bw from 2130h to 2230h) and placebo IV infusion. Serum GH and PRL levels were normal under basal conditions and no effects were noted after the infusion of DSIP. The GH and PRL circadian rhythm was not modified by DSIP administration. DSIP did not influence GH and PRL responsiveness to arginine chlorhydrate. We found that at dosages which are known to modify ECG patterns, DSIP is unable to modify spontaneous or arginine chlorhydrate-induced GH and PRL secretion.
Study Information
pubmed
1993
10.1016/0306-4530(93)90057-r