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DSIP

Emideltide, DSIP nonapeptide, Delta sleep-inducing peptide

Quick Stats
Studies 458
Trials 82
Overview Studies Clinical Trials
Score 3
1992 pubmed

Delta sleep-inducing peptide as a factor increasing the content of substance P in the hypothalamus and the resistance of rats to emotional stress.

Salieva. R M RM; Yanovskii. K K; Ratsak. R R; Oeme. P P; Sudakov. K V KV; Yumatov. E A EA

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Key Findings

  • DSIP (60–120 nmol/kg, i.p.) significantly increased hypothalamic substance P content in both stress‑resistant and stress‑prone rats.
  • A one‑time dose given before stress prevented the stress‑induced drop in hypothalamic substance P.
  • A single 60 nmol/kg dose reduced classic stress markers: adrenal hypertrophy and thymus involution.

Practical Outcomes

  • The study suggests DSIP might blunt acute stress responses by boosting substance P, but the data are limited to rodents and an intraperitoneal route. For biohackers, low‑dose DSIP could be explored as a pre‑stress supplement, yet human dosing, safety, and efficacy remain unproven, so cautious, experimental use is advised.

Summary

In rats, giving the peptide delta sleep‑inducing peptide (DSIP) raised levels of the brain chemical substance P and lessened typical stress signs like enlarged adrenal glands and shrinking thymus. A single dose before a stressful situation was enough to keep substance P up and reduce stress‑related organ changes.

Abstract

The influence of delta sleep-inducing peptide (DSIP, 60 and 120 nmole/kg, intraperitoneally) on the content of substance P (SP) in the hypothalamus of rats was studied in male rats of the August line. It was demonstrated that the administration of DSIP significantly increases the average content of SP in the hypothalamus, as well as its content in animals resistant to and predisposed to emotional stress. A daily one-time administration of DSIP before placing the rats in conditions of stress increases the content of SP in the hypothalamus which was decreased during emotional stress. The preliminary one-time administration of DSIP to animals subjected to a stressor influence also increases the SP content in the hypothalamus. It was established that a one-time administration of DSIP in a dose of 60 nmole/kg sharply decreases the classical manifestations of stress such as the hypertrophy of the adrenals and involution of the thymus.

Study Information

Provider

pubmed

Year

1992

DOI

10.1007/bf01182865