Delta sleep-inducing peptide (DSIP) stimulates LH release in steroid-primed ovariectomized rats.
Sahu. A A; Kalra. S P SP
Key Findings
- DSIP (2‑30 µg) rapidly increased LH release in estrogen‑ and progesterone‑primed ovariectomized rats.
- DSIP had no effect on LH release in non‑primed ovariectomized rats or when given directly to pituitary tissue in vitro.
- The results support the idea that DSIP may trigger hypothalamic pathways that naturally boost LH during sleep.
Practical Outcomes
- For biohackers interested in hormone modulation, this study suggests DSIP could influence LH—but only under very specific hormonal conditions that are not typical in humans. The animal model and dosing details are far from a usable human protocol, so it’s more of a mechanistic hint than a ready‑to‑use supplement strategy.
Summary
In rats that had their ovaries removed but were given estrogen and progesterone, giving the peptide DSIP caused a quick rise in luteinizing hormone (LH), a hormone that helps control reproductive function. The same effect wasn’t seen in rats without hormone priming, and DSIP didn’t work directly on pituitary tissue in a dish.
Abstract
Delta sleep inducing peptide (DSIP) has been shown to increase sleep in various animals and it is found in various parts of the brain including the hypothalamus. While intraventricular administration of DSIP (2 or 10 micrograms) failed to affect LH release in ovariectomized rats, in two separate experiments DSIP (2 or 10; 15 or 30 micrograms) promptly stimulated LH release in ovariectomized estrogen, progesterone-primed rats. However, DSIP (10(-8) or 10(-6)M) had no effect on either basal or luteinizing hormone-releasing hormone-induced in vitro LH release from the hemipituitaries of ovarian steroid-primed rats. These findings are in accord with the hypothesis that DSIP or DSIP-like peptide(s) may activate the hypothalamic neural circuitry responsible for stimulation of LH release reported to occur during sleep.
Study Information
pubmed
1987
1987-03-23T00:00:00.000Z
10.1016/0024-3205(87)90239-6
20
19