Potent antinociceptive effect of centrally administered delta-sleep-inducing peptide (DSIP).
Nakamura. A A; Nakashima. M M; Sugao. T T; Kanemoto. H H; Fukumura. Y Y; Shiomi. H H
Key Findings
- Central (ICV or intracisternal) administration of DSIP produces dose‑dependent pain relief in mice and rats.
- The pain‑relieving effect is blocked by naloxone, indicating involvement of opioid receptors.
- DSIP is ineffective when given intrathecally or in morphine‑tolerant animals, suggesting a supraspinal, opioid‑mediated mechanism.
Practical Outcomes
- Because the peptide must be injected directly into the brain, this finding isn’t a practical protocol for most biohackers. It does hint that DSIP could influence central pain pathways via opioid systems, but any real‑world use would require non‑invasive delivery methods that are not yet proven. For now, the study offers limited actionable insight for self‑experimentation.
Summary
A study in mice and rats found that giving delta-sleep‑inducing peptide (DSIP) directly into the brain reduces pain responses, but this effect only works when the peptide is delivered straight into the brain's fluid spaces and is blocked by an opioid blocker. It doesn't work when given into the spinal cord, and it doesn't help animals already tolerant to morphine.
Abstract
The effect of central administration of delta-sleep-inducing peptide (DSIP) on nociceptive responses was evaluated in mice and rats. DSIP, administered intracerebroventricularly or intracisternally to mice, produced a significant dose-dependent antinociceptive effect in the tail-pinch and hot-plate tests. Intrathecal administration of DSIP did not produce such an effect. The antinociceptive effect of DSIP was blocked by pretreatment with the opioid antagonist, naloxone. Moreover, DSIP did not produce an antinociceptive effect in morphine-tolerant mice. Similar antinociceptive effects of DSIP were observed in rats. These results suggest that DSIP produces an antinociceptive effect by acting at the supraspinal level and that this effect is mediated via the opioid receptor, either directly or indirectly. DSIP may play an important role in pain regulation in the central nervous system.
Study Information
pubmed
1988
1988-10-18T00:00:00.000Z
10.1016/0014-2999(88)90510-9
17
25