The effect of subcutaneous administration of delta sleep-inducing peptide (DSIP) on some parameters of sleep in the cat.
Susić. V V
Key Findings
- DSIP (120âŻnmol·kgâ»Âč, subcutaneous) significantly increased slowâwave (delta) sleep in cats.
- There was a nonâsignificant trend toward less waking time, shorter sleepâonset latency, and shorter REMâsleep latency.
- The total amount of REM sleep was unchanged.
Practical Outcomes
- The results suggest DSIP can raise deepâsleep brain activity in cats, but the study provides no clear guidance for humans. Without human data, dosage, safety, and effectiveness remain unknown, so biohackers should not adopt this protocol yet. More research in people is needed before any realâworld use.
Summary
A study in eight cats showed that giving delta sleepâinducing peptide (DSIP) under the skin boosted the amount of deep, slowâwave sleep on the EEG, but it didnât significantly change how long the cats stayed awake, how quickly they fell asleep, or how much REM sleep they got.
Abstract
Delta sleep inducing peptide (DSIP) significantly increases deep-slow-wave sleep (DSWS) of cats after subcutaneous (SC) injection. Cats (n = 8) were SC injected with DSIP (120 nmol.kg-1) prior to polygraphic recording of EEG combined with electro-oculography, EOG) and electromyography (EMG) for 8 hours. DSIP was found to significantly increase slow-waves (delta sleep) in the sleep EEG. There was a tendency to reduced waking time and a prolongation of slow wave sleep time, and a shortening of sleep onset and REM sleep latencies but the differences from control (Ringer injection) were not statistically significant. There was no change in the amount of REM sleep. These findings support the belief that DSIP can increase sleep wave activity when administered by peripheral route.
Study Information
pubmed
1987
1987-12-31T00:00:00.000Z
10.1016/0031-9384(87)90098-9
4
15