Central nervous system effects of peptides, 1980-1985: a cross-listing of peptides and their central actions from the first six years of the journal Peptides.
Zadina. J E JE; Banks. W A WA; Kastin. A J AJ
Key Findings
- Over 80 peptides and 135 central nervous system effects were compiled into two cross‑referencing tables.
- DSIP (Delta Sleep‑Inducing Peptide) is listed among peptides that influence sleep, aggression, and other behaviors.
- The tables include details on injection routes, species used, direction of effect (increase/decrease), and brief notes.
Practical Outcomes
- This review can be used as a quick lookup to see what CNS actions have been reported for DSIP and other peptides, helping you decide which effects are worth investigating further. However, it provides no dosage, safety, or protocol guidance, so you’ll need to dig into the original studies for actionable dosing or supplementation plans.
Summary
The paper is a catalog of more than 80 brain‑active peptides (including DSIP) and the dozens of effects they have shown in animal studies from 1980‑85. It doesn’t present new experiments or dosing advice, just a handy reference table that links each peptide to things like sleep, aggression, feeding, memory, etc.
Abstract
A tabular synopsis is presented for articles concerned with the effects of peptides on the central nervous system that appeared in the journal Peptides from 1980-1985. A table arranged alphabetically by peptide and one arranged by effects, both listing routes of injection, species, direction of change, and qualifying notes, provides easy cross-referencing of peptides and their effects. Over 80 peptides and over 135 effects are listed. The list of peptides includes, but is not limited to: ACTH, angiotensin, bombesin, bradykinin, calcitonin, casomorphin, CCK, ceruletide, CGRP, CRF, dermorphin, DSIP, dynorphin, endorphins, enkephalins, GRF, gastrin, LHRH, litorin, metkephamid, MIF-l, motilin, MSH, NPY, NT, oxytocin, ranatensin, sauvagine, substances P and K, somatostatin, TRH, VIP, vasopressin, and vasotocin. The list of effects includes, but is not limited to: aggression, alcohol, analgesia, attention, avoidance, behavior, cardiovascular regulation, catalepsy, conditioned behavior, convulsions, dopamine binding and metabolism, discrimination, drinking, EEG, exploration, feeding, fever, gastric secretion, GI motility, grooming, learning, locomotor behavior, mating, memory, neuronal activity, open field, operant behavior, rearing, respiration, satiety, scratching, seizure, sleep, stereotypy, temperature, thermoregulation and tolerance.
Study Information
pubmed
1986
1986-05-01T00:00:00.000Z
10.1016/0196-9781(86)90020-3
54
390