Influence of delta-sleep inducing peptide on melatonin synthesis in the rat pineal gland.
Oaknin. S S; Troiani. M E ME; Webb. S M SM; Reiter. R J RJ
Key Findings
- A 15 nmol/kg dose of DSIP delayed the nighttime increase in pineal N‑acetyltransferase activity and melatonin levels at 3 hours after lights out.
- Higher doses (30 and 60 nmol/kg) did not produce this delay, and the effect disappeared at later night time points (01:00, 03:00) and the next morning.
- The impact of DSIP on melatonin synthesis appears brief and dose‑specific in rats.
Practical Outcomes
- For biohackers, this research suggests DSIP might temporarily influence sleep‑related hormone production, but the effect is short‑term and only seen at a specific low dose in rats. There isn’t enough evidence to create a reliable human dosing protocol, so caution and further study are needed before applying it to longevity or performance regimens.
Summary
A study in rats showed that a low dose of delta‑sleep inducing peptide (DSIP) briefly slowed the early‑night rise of melatonin, the hormone that helps regulate sleep. The effect was short‑lived and didn’t show up at higher doses or later in the night.
Abstract
The influence of delta-sleep inducing peptide (DSIP) on rat pineal N-acetyltransferase (NAT) activity and melatonin levels was examined. Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20:00 h, immediately before lights out. DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity and melatonin levels at 3 h into the dark phase. At the other two nocturnal time points (01:00 and 03:00 h) and the following morning (08:00 h) pineal NAT activity and melatonin levels were similar in all groups. The results confirmed a short-lived, dose-specific effect of DSIP on serotonin metabolism in the rat pineal gland.
Study Information
pubmed
1986
1986-09-25T00:00:00.000Z
10.1016/0304-3940(86)90450-7
3
14