Coexistence of delta sleep-inducing peptide and serotonin in midgut carcinoid tumour cells in vivo and in vitro.
Ahlman. H H; Ahlund. L L; Nilsson. O O; Dahlström. A A; Bjartell. A A; Ekman. R R
Key Findings
- DSIP and serotonin are found together in most midgut carcinoid tumor cells.
- Cultured tumor cells release DSIP‑like peptides into the surrounding medium.
- DSIP does not serve as an effective clinical tumor marker.
- Stimulating patients with pentagastrin raises serotonin levels but not DSIP levels.
Practical Outcomes
- For biohackers and self‑directed health optimizers, this research offers no actionable information. It does not suggest any new uses, dosages, or protocols for DSIP related to longevity, metabolism, or performance.
Summary
The study found that a peptide called delta sleep‑inducing peptide (DSIP) is present together with serotonin in certain gut tumor cells, but it doesn't seem useful as a disease marker and doesn't change when serotonin levels are boosted.
Abstract
By immunocytochemistry, delta sleep-inducing peptide (DSIP) was demonstrated to coexist with serotonin (5-HT) in a majority of midgut carcinoid tumour cells studied in biopsies and long-term cell cultures. Tumour cell colonies were characterized ultrastructurally and by confocal laser microscopy. The cultures produced several DSIP-like peptides chromatographically separated from culture media. DSIP has not yet proved to be a useful tumour marker clinically. Provocation with pentagastrin in patients with midgut carcinoid syndrome resulted in increased peripheral levels of 5HT, but not of DSIP.
Study Information
pubmed
1989
1989-10-15T00:00:00.000Z
10.1002/ijc.2910440414
2
21