CSF-plasma relationships for DSIP and some other neuropeptides.
Banks. W A WA; Kastin. A J AJ
Key Findings
- Blood (plasma) DSIP levels strongly correlate with CSF (brain) DSIP levels.
- Similar correlation found for gastrin; weaker or no correlation for other peptides like VIP.
- CSF/plasma ratios and BBB disruption effects differ between peptides, implying specific transport mechanisms.
Practical Outcomes
- For biohackers, measuring DSIP in blood could serve as a proxy for brain exposure, supporting the use of peripheral DSIP dosing to influence sleep or cognition. However, the study doesn’t give dosing guidelines, so start with low, well‑tolerated doses and monitor blood levels if possible.
Summary
The study shows that the amount of DSIP (a sleep‑related peptide) in the blood matches the amount in the brain fluid, meaning blood levels can hint at what's happening in the brain. This suggests that taking DSIP by injection or other peripheral routes could actually reach the brain, though the exact way it gets across the blood‑brain barrier isn’t clear.
Abstract
The relationships between CSF and plasma hormonal levels of several peptides were studied in the same samples of simultaneously obtained plasma and CSF. A significant correlation existed between CSF and plasma levels of DSIP as well as gastrin. Preliminary results also showed a correlation between CSF and plasma levels of NT, but not VIP or calcitonin. CSF/plasma ratios and the effect of BBB disruption also varied from peptide to peptide. These diverse CSF/plasma relationships are not easily explained by models of nonspecific passage but may indicate individual systems or axes that could be involved in the central effects of peripherally administered peptides.
Study Information
pubmed
1983
1983-12-01T00:00:00.000Z
10.1016/0091-3057(83)90412-4
22
21