Effects of DSIP on narcolepsy.
Schneider-Helmert. D D
Key Findings
- DSIP reduced the frequency of daytime sleep attacks in a narcoleptic patient.
- Participants reported higher alertness, activity, and better performance during waking hours.
- Nighttime sleep was compressed with a relative increase in REM sleep.
Practical Outcomes
- DSIP may help some people feel more alert and compress sleep, but the evidence comes from only one case. Biohackers should treat this as a very early hint, not a proven protocol, and proceed with caution, low doses, and close monitoring if they choose to experiment.
Summary
A single 35‑year‑old man with narcolepsy took repeated doses of the peptide DS‑IP. He reported fewer sudden sleep attacks, felt more awake and performed better during the day. His nighttime sleep got shorter but had more REM sleep, which the authors think is due to DS‑IP boosting the body's natural sleep‑wake rhythms.
Abstract
Repeated injections of delta sleep-inducing peptide (DSIP) were given to a 35-year-old male narcoleptic. Effects on wakefulness and sleep were evaluated by self-reports, performance tests, multiple sleep latency test and all-night polysomnography. DSIP reduced the frequency of sleep attacks and increased activity, alertness and performance during day-time. The sleep period was compressed by DSIP with enhancement of REM sleep. The results suggest that the effects are due to an accentuation of circadian and ultradian rhythms by DSIP.
Study Information
pubmed
1984
10.1159/000115713
9