Reduced sleep in cats after intraperitoneal injection of delta-sleep-inducing peptide (DSIP).
Sommerfelt. L L
Key Findings
- DSIP injection reduced total sleep time in cats.
- Light slow‑wave (stage 2) sleep was specifically decreased.
- REM sleep duration dropped and REM latency (time to first REM) increased.
Practical Outcomes
- For people experimenting with DSIP as a sleep aid, this animal data suggests it may have the opposite effect and could keep you more awake. Until human studies confirm safety and efficacy, it’s wise to be cautious and consider alternative compounds for sleep optimization.
Summary
A study in cats found that giving delta‑sleep‑inducing peptide (DSIP) by injection actually cut down the amount of sleep, especially light deep sleep and REM sleep, and made REM sleep start later. In other words, instead of helping sleep, DSIP made the cats stay awake longer.
Abstract
The effect of intraperitoneally injected delta-sleep-inducing peptide (DSIP) on sleep-wakefulness in cats was studied using EEG, EMG and EOG recording for 10 h following 30 nmol/kg DSIP or control saline i.p. injections. DSIP reduced the amount of sleep, specifically light slow-wave sleep and REM sleep, and REM sleep latency was increased. The results suggest that in cats with redundancy sleep DSIP increases wakefulness at the cost of light slow-wave sleep, and in addition it has a specific REM-reducing effect.
Study Information
pubmed
1985
1985-07-04T00:00:00.000Z
10.1016/0304-3940(85)90331-3
2
15