Aluminium increases permeability of the blood-brain barrier to labelled DSIP and beta-endorphin: possible implications for senile and dialysis dementia.
Banks. W A WA; Kastin. A J AJ
Key Findings
- Aluminium chloride injection increased BBB permeability to DSIP and beta‑endorphin by about 60‑70% in rats.
- The effect was observed with a small peptide (DSIP) that is often used by biohackers for sleep and recovery.
- The authors propose that aluminium‑induced BBB leakage could contribute to neurodegenerative conditions like Alzheimer’s and dialysis dementia.
Practical Outcomes
- If you’re using DSIP or other brain‑active peptides, limit exposure to aluminium sources (e.g., certain cookware, antacids, contaminated water) to avoid unintended changes in brain access. This study doesn’t change DSIP dosing but highlights a potential safety concern worth monitoring in your overall health protocol.
Summary
A rat study found that giving aluminium chloride makes the blood‑brain barrier more leaky, letting small peptides like the sleep‑inducing peptide DSIP and beta‑endorphin pass through 60‑70% more easily. This suggests aluminium could help harmful substances get into the brain and might play a role in dementia.
Abstract
The primary lesion in Alzheimer's disease and dialysis dementia has been postulated to be an impaired blood-brain-barrier (BBB) permeability that allows neurotoxins like aluminium to reach the central nervous system. The present study shows that aluminium itself affects the permeability of the BBB of rats to small peptides. Intraperitoneal injection of aluminium chloride increased the permeability of the BBB to iodinated N-Tyr-delta-sleep-inducing peptide and beta-endorphin by 60-70%. Thus, aluminium can affect the BBB in ways that might be involved in dementia.
Study Information
pubmed
1983
1983-11-26T00:00:00.000Z
10.1016/s0140-6736(83)91273-4