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DSIP

Emideltide, DSIP nonapeptide, Delta sleep-inducing peptide

Quick Stats
Studies 458
Trials 82
Overview Studies Clinical Trials
Score 3
1986 pubmed

Sleep-wave activity of a delta sleep-inducing peptide analog correlates with its penetrance of the blood-brain barrier.

Miller. L H LH; Turnbull. B A BA; Kastin. A J AJ; Coy. D H DH

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Key Findings

  • Peripheral (i.p.) injection of DSIP increases delta‑wave activity in rat EEG.
  • The analog [D-Ala4]DSIP‑NH2, which crosses the blood‑brain barrier more easily, produces even more delta waves plus significant theta activity.
  • The analog reduces locomotor activity, while the original DSIP does not affect movement.

Practical Outcomes

  • The study suggests DSIP could be used to enhance deep‑sleep quality, but it’s based on rat injections, not oral or human use. Biohackers might consider that a brain‑penetrant DSIP analog could be more effective, yet dosing, safety, and delivery method in humans remain unknown and need further research.

Summary

In rats, a peptide called DSIP and a more brain‑penetrant version of it boost deep‑sleep brain waves (delta) when injected under the skin, and the analog also adds theta waves and makes the animals less active. This shows that DSIP can reach the brain from the bloodstream and influence sleep patterns.

Abstract

Delta sleep-inducing peptide (DSIP) significantly increases delta wave electrical activity in the brain of rats after intraperitoneal (i.p.) injection. Rats (n = 10) were peripherally injected with DSIP and [D-Ala4]DSIP-NH2 during the dark portion of a 12-h light/dark cycle prior to recording of epidural encephalographic (EEG) wave forms. Administration of [D-Ala4]DSIP-NH2, an analog that enters the brain after peripheral administration more readily than the parent DSIP molecule, resulted in significantly more delta waves than DSIP together with a highly significant amount of theta activity. DSIP was found to significantly increase EEG output in the delta range when compared with controls. In addition, the DSIP analog significantly decreased locomotor activity, whereas DSIP itself was without effect. These findings strongly support the controversial concepts that peripherally injected peptides can reach the brain and that DSIP compounds can increase sleep activity.

Study Information

Provider

pubmed

Year

1986

DOI

10.1093/sleep/9.1.80