Tyr-MIF-1 and MIF-1 are active in the water wheel test for antidepressant drugs.
Kastin. A J AJ; Abel. D A DA; Ehrensing. R H RH; Coy. D H DH; Graf. M V MV
Key Findings
- MIF‑1 and Tyr‑MIF‑1 increased wheel‑turning behavior in mice, indicating antidepressant‑like activity.
- Effective at doses as low as 0.01 mg/kg administered intraperitoneally; MIF‑1 showed an inverted‑U dose‑response curve.
- DSIP decreased wheel turning, and neither peptide reversed the depressive‑like effect of morphine.
Practical Outcomes
- The results hint that MIF‑1 and Tyr‑MIF‑1 might have mood‑boosting properties, but the evidence is limited to an animal model with injectable dosing. For biohackers, there’s no clear, safe protocol for human use yet, so more research is needed before considering self‑experimentation.
Summary
In mice, two short peptides called MIF-1 and Tyr‑MIF‑1 made the animals turn a water‑wheel more often, which is a behavior linked to antidepressant effects. The effect showed up at very low doses (0.01 mg/kg) given by injection, while another peptide (DSIP) actually reduced wheel turning. The study didn’t test these peptides in people or show they can reverse opioid effects.
Abstract
MIF-1 [Pro-Leu-Gly-NH2] and Tyr-MIF-1 [Tyr-Pro-Leu-Gly-NH2] were tested in a system in which antidepressant drugs are known to result in increased wheel turning as mice attempt to escape from a small tank of water. One hr after injection, both peptides were found to cause a significant increase of the number of rotations of the wheel at doses as low as 0.01 mg/kg IP, the dose-response pattern for MIF-1 resembling an inverted-U. DSIP and morphine, by contrast, decreased the number of rotations. Under the conditions tested, neither MIF-1 nor Tyr-MIF-1 reversed the effect of morphine. The results demonstrate that MIF-1 and Tyr-MIF-1 are active in another test for antidepressants.
Study Information
pubmed
1984
10.1016/s0091-3057(84)80017-9