DSIP-induced changes of the daily concentrations of brain neurotransmitters and plasma proteins in rats.
Graf. M M; Baumann. J B JB; Girard. J J; Tobler. H J HJ; Schoenenberger. G A GA
Key Findings
- DSIP caused the biggest increase in daytime serotonin levels.
- Both dopamine and norepinephrine levels were altered, with different patterns for morning vs. evening dosing.
- Plasma proteins and corticosterone (a stress hormone) also shifted after DSIP injection.
- The timing of the injection mattered: morning and evening doses produced distinct profiles across the 24‑hour cycle.
Practical Outcomes
- The study suggests that DSIP may do more than just promote sleep—it can modulate neurotransmitters and stress markers in a time‑dependent way. For biohackers, this hints that the time of day you take DSIP could influence mood, stress response, or metabolic effects, but human data are still missing and the IV route used in rats isn’t directly applicable to typical self‑administration.
Summary
In rats, a single IV dose of delta sleep‑inducing peptide (DSIP) changed brain chemicals like serotonin, dopamine and norepinephrine, as well as blood proteins and stress hormone levels, and these changes varied depending on whether the peptide was given in the morning or evening.
Abstract
The influence of delta sleep-inducing peptide (DSIP) on the brain neurotransmitters 5-HT, dopamine and norepinephrine and plasma proteins/corticosterone concentrations for four time points within the 24 hr following IV injection of 30 nmol/kg was investigated in rats. DSIP administered in the morning or in the evening respectively induced changes in nearly all measured parameters. Different effects were observed for different times of administration. The most marked changes were found in the level of serotonin during daytime. In view of the multivariate results obtained by measuring several parameters at multiple time points, a method was developed to describe the time-dependent changes. By means of "circadian rhythm statistics" based on a statistical likelihood analysis we found that multiple and different changes within the factor's daily variation are induced by one injection of DSIP. A multidimensional scaling of the results provides further insights into the correlations of the DSIP-induced effects on plasma and brain factors which are therefore tentatively termed "programming functions." These apparently involve not just sleep induction but also act on multiple parameters within the 24 hr rest-activity period.
Study Information
pubmed
1982
1982-09-01T00:00:00.000Z
10.1016/0091-3057(82)90312-4
18
20