The influence of synthetic DSIP (delta-sleep-inducing-peptide) on disturbed human sleep.
Schneider-Helmert. D D; Schoenenberger. G A GA
Key Findings
- DSIP (25 nmol/kg IV) increased total sleep time and improved sleep quality.
- Participants experienced fewer nighttime interruptions and a modest rise in REM sleep.
- No daytime sedation or other side effects were reported.
- The sleep‑enhancing effect began after the first hour post‑injection, with a brief arousing effect in the first hour.
- The beneficial effect lasted for up to six hours of night‑time sleep.
Practical Outcomes
- For biohackers interested in sleep optimization, an IV dose of DSIP at 25 nmol per kg may help chronic insomniacs achieve deeper, longer sleep without next‑day drowsiness, but expect a short period of increased alertness right after injection. Timing the dose about an hour before bedtime could align the sleep‑enhancing window with the typical sleep period. Larger studies are needed to confirm safety and efficacy.
Summary
A small study gave six middle‑aged people with chronic insomnia an IV dose of synthetic DSIP and found they slept longer, had better quality sleep with fewer wake‑ups, and got a bit more REM sleep, without feeling groggy the next day. The sleep boost started about an hour after the injection and lasted up to six hours.
Abstract
The effects of acute intravenous administration of synthetic DSIP, 25 nmoles/kg b.wt, on disturbed human sleep were tested in 6 middle-aged chronic insomniacs. The results were: longer sleep duration and a higher quality of sleep with fewer interruptions; slightly more REM-sleep, but no day-time sedation or other side effects though the sleep enhancing capacity was seen for up to 6 h of night sleep. Sleep-promoting effects occurred only in the second hour after injection, in the first hour a slight arousing effect was indicated. The study corroborates the findings of previous investigations in healthy subjects and shows that DSIP has a normalizing influence on human sleep regulation.
Study Information
pubmed
1981
10.1007/bf01971753