Peptides and thermoregulation.
Yehuda. S S; Kastin. A J AJ
Key Findings
- DSIP (and other peptides) can influence body temperature (thermoregulation).
- The thermal effect of these peptides changes with ambient temperature and the route of administration.
- Peptides can modify the temperature‑changing actions of drugs such as d‑amphetamine, morphine, and naloxone.
Practical Outcomes
- If you experiment with DSIP, expect its impact on body heat to depend on the environment and how you administer it (e.g., injection vs. nasal). It may alter how stimulants or opioids feel temperature‑wise, so monitor your core temperature and adjust dosing or setting accordingly. However, the abstract provides no specific dosing guidance, so use caution and start with very low amounts.
Summary
The abstract says that a handful of peptides, including DSIP, can change how the body controls temperature. Their effects vary depending on the surrounding temperature and how the peptide is taken, and they can interact with drugs like amphetamine, morphine, or naloxone that also affect heat regulation.
Abstract
Several peptides are now known to affect thermoregulation. These include beta-endorphin, bombesin, MIF-I, alpha-MSH, neurotensin, TRH, and DSIP. Some of these have been found to interact with the thermal effects of d-amphetamine, a drug with well established actions on thermoregulation. The effects of morphine on body temperature provide some notable comparisons with beta-endorphin, as do the similarities between the effects of naloxone and MIF-I. In general, it seems that two of the major variables which interact and modify the thermal effects of peptides are ambient temperature and route of administration.
Study Information
pubmed
1980
1980-12-01T00:00:00.000Z
10.1016/0149-7634(80)90035-4
95
77